Cannabidiol Side Effects: What Are the Side Effects of CBD?

Cannabidiol (CBD) and THC are the two best-known compounds in cannabis. Even though they are quite alike, they don’t have the same characteristics and work differently on the body. But do THC and CBD have side effects?

THC is responsible for the “high” sensation you get after consuming cannabis for recreational purposes. It achieves this by binding to CB1 receptors in the brain and comes packed with anti-inflammatory, analgesic and neuroprotective properties. However, THC is not regarded as a viable treatment options, because usually the side effects outweigh the benefits.

CBD offers plenty of health benefits, including antiemetic, antioxidant, anti-tumor and anticonvulsant properties, but can also inhibit the psychoactive effects of THC. CBD also works as a neuroprotector and antidepressant. Once again, CBD is not psychoactive and psychotropic, so it won’t get you high or stoned.

Let’s take a closer look at the side effects of CBD.


Side Effects of Cannabidiol

There are multiple studies that show CBD is effective for several conditions and practically free of side effects. Here are a few studies that detail the potential side effects of Cannabidiol.

A 2011 review on the safety and side effects of cannabidiol established that CBD is well tolerated in humans and does not affect physiological parameters such as blood pressure, heart rate or body temperature. What’s more CBD is non-toxic and does not influence how much food you eat. Cannabidiol does not affect psychological and psychomotor functions and does not alter gastrointestinal transit. The review specifies chronic use and high doses of up to 1,500mg/day of Cannabidiol are well tolerated by the body.

Some potential side effects of CBD are inhibition of hepatic drug metabolism, reduced fertilization capacity, alterations of in vitro cell viability and decreased activities of p-glycoprotein.

Because CBD inhibits the activity of P450 (an enzyme in the liver), it may interact with some drugs. CBD may nullify the activity of the P450 enzymes by metabolizing most of the drugs and changing how the body processes drugs. However, this potential side effect is not an all-out negative thing, as neutralizing the P450 enzymes is a mechanism through which CBD also inhibits the side effects of THC. As a comparison, consuming grapefruit can have a similar effect on those enzymes.

Another study found administering oral doses ranging from 100 to 600mg/day of CBD to patients with dystonic movement disorders for a period of 6 weeks can cause mild side effects such as lightheadedness, drowsiness and dry mouth. The latter effect may be due to the fact that the body’s own endocannabinoid system has a role in inhibiting saliva secretion.

A 2006 research also noted that cannabinoid receptors can be found in salivary glands to mediate the effect of decreased saliva secretion. Taking CBD activates these receptors and may cause mouth dryness.

There’s also some evidence that suggests Cannabidiol may worsen muscle movement and resting tremor in those suffering with Parkinson’s. However, there are some studies that show the contrary, proving CBD is safe for patients with Parkinson’s.

As a dosage, Cannabidiol is possibly safe when taken by mouth in doses of up to 300mg/day for up to 6 months. When it comes to higher doses, you can take 1200-1500mg/day, but for no longer than 4 weeks.


CBD Oil Side Effects Conclusion

CBD can be used for various diseases and symptoms, working to treat anxiety, chronic pain, inflammation, heart disease, arthritis, epilepsy, infections, PTSD, neurological problems. It has been used in cancer treatment and considered as a possible treatment for schizophrenia.

As a conclusion, there shouldn’t be any real health concerns when taking CBD. Aside from a dry mouth, CBD is likely to be safe if you’re not suffering with more serious diseases such as Parkinson’s. It is recommended you consult with your physician before starting with Cannabidiol if you have a serious disorder or illness, or if you are pregnant or breastfeeding.

CBD applications are still being explored and further studies are needed to know the full potential of Cannabidiol.


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