cAMP and Forskolin: It’s well known that Forskolin works to increase cAMP levels, but what is cAMP exactly and how does it influence weight loss?
While some manufacturers might say that their supplement contains cAMP Forskolin, they are either misinformed or misinforming you. Forskolin does not contain cAMP, but rather works to increase cAMP levels. Here’s everything you need to know about cAMP, Forskolin and how they work to help you lose weight.
What Is it with cAMP and Forskolin?
cAMP (Cyclic adenosine monophosphate or cyclic AMP) is a type of intracellular second messenger that has a role in various biological processes. cAMP is one of the most important cell-regulating compounds, playing an important part in multiple cellular functions. Forskolin is unique because it has been found to increase cAMP levels without help from neurotransmitters of hormones.
cAMP is synthesized from ATP by adenylate cyclase (AC), which can be activated by signaling molecules such as colforsin daropate or FSK88. But Forskolin does not just activate adenylate cyclase, as it also interacts with specific proteins that include ion channels and glucose transporters.
cyclic AMP is used for intracellular signal transduction, helping to transfer the effects of hormones such as adrenaline and glucagon into cells. Otherwise, these hormones would not pass through plasma membrane. What’s more, cAMP regulates the function of ion channels.
cAMP impacts several biological processes and helps cells understand how to handle messages coming from first messengers such as serotonin or epinephrine. Reduced intracellular levels of cyclic AMP have been linked to obesity, asthma, psoriasis, eczema, hypertension or angina.
How Does Forskolin Activate cAMP?
Adenylate cyclase produces cAMP, which of crucial importance to all cells. cAMP is involved in immune reactions, but also activates several proteins, including protein kinase, which maintains energy balance and how cells react to hormones.
So, Forskolin stimulates adenylate cyclase, which increases cAMP levels. When Forskolin increases cAMP levels, it works to:
- Stimulate lipolysis in fat cells (fat burning)
- Improve thyroid hormone secretion
- Promote vasodilation (widening of blood vessels)
- Increase bronchodilatation (improved breathing)
- Inhibits platelet aggregation (prevents blood clotting)
- Lower blood pressure
- Reduces release of histamine by cells (reduces allergies)
- Reduce intraocular pressure
But Forskolin doesn’t just increase thyroid hormone levels to boost weight loss, but also works – through cAMP – to increase the levels of protein kinase. In turn, this enzyme activates hormone-sensitive lipase, which is directly involved in the breakdown of triglycerides — the building blocks of fatty tissue.
Other cAMP Benefits
cAMP reduces inflammation by inhibiting a protein (RAGE) that starts the development of inflammation, but may also work to support immune cell production of substances that aid in soothing chronic inflammation.
Forskolin is also good for nerve cells, as cAMP has multiple roles in processes that deal with nerve cell protection and development. What’s more, cyclic AMP has been used in post-injury nerve therapy, having been found to promote nerve cell growth and regeneration after injury.
cAMP levels inside cells can also influence eye retina development, with higher levels being linked to normal eye retina health and development.
Elevated brain cyclic AMP levels have also been linked to antidepressant activity in animal models of depression. Forskolin has been found to improve overall cardiovascular performance in one study involving seven patients with dilated cardiomyopathy.
Increasing cyclic AMP levels is a popular treatment option in the case of allergies and asthma, promoting bronchodilatation, increasing vital capacity and forced expiratory volume and reducing airway resistance. This, along with its antispasmodic properties, is why Coleus forskohlii root extract has been used since ancient times to relieve angina, hypertension and intestinal colic.
cAMP, Forskolin and Weight Loss
Studies show Forskolin increases cAMP levels (through adenylate cyclase) and thus stimulates the breaking down of fats in fat cells, which is called lipolysis. One study from Penn State University even discovered that there’s a connection between many obese people and a lower production of cyclic AMP. They theorized that Forskolin might be especially effective for weight loss in those with impaired cAMP production.
One study observed the effects of Forskolin on six overweight women who were taking 250mg of 10% Forskolin twice daily for a period of eight weeks. When the trial ended, the participants were found to have lost 10 pounds and reduced body fat by almost 8 percent. The study also revealed blood pressure was lower during the test and concluded that Forskolin may be a safe and useful way to lose weight and have normal body composition.
Obesity is associated with high leptin levels, but cyclic AMP-activated mechanisms work to decrease leptin. Also called “the satiety hormone”, leptin is known to suppress appetite and stimulate energy expenditure.
It has also been revealed that a lack of CREB, which is a cAMP-activated protein, in the brain can be a factor that can lead obesity.
How to Increase cAMP Levels with Forskolin
So, Forskolin increases cAMP levels, which mimics the effects of exercise and dieting. One study has found obese people have a reduced production of cAMP, so increasing cyclic AMP levels not only protects against weight gain, but also offers multiple health benefits with no side effects.
Here are a few popular Forskolin supplements containing the ideal concentration of 20% Forskolin root extract and 250mg dosage.
Forskolin Fit Pro